In orthopaedics, stem cells can be obtained from bone marrow (HSC – haematopoietic stem cells) or adipose tissue (MSC – mesenchymal stem cells).
Stem cells are cells that can differentiate (transform) into other cells of the human body, such as cartilage, bone and muscle cells. They are used to regenerate and repair damaged tissues.
Where can stem cells be obtained?
How do stem cells work?
Stem cells can differentiate into other human cells. The main mechanism of mesenchymal stem cells from adipose tissue is directing tissue-repair processes. Stem cells introduced into a joint release microparticles which, through growth factors, cytokines, RNA and DNA, direct tissue repair.
What can be treated with stem cells?
- osteoarthritis
- post-traumatic cartilage damage
- as an adjunct in surgical treatment of meniscal injuries of the knee
- impaired bone union – pseudoarthrosis
- bone necrosis
- hard-to-heal wounds
What does stem-cell therapy involve?
We obtain mesenchymal stem cells from adipose tissue by taking a small amount of subcutaneous fat from the abdomen. The procedure is performed under anaesthesia with so-called light sedation (the patient sleeps during the procedure). A small amount of fat is collected through an approximately 7 mm abdominal incision using a special cannula. A separator resembling dialysis membranes then separates the stem cells. The prepared cell suspension is injected into the joint.
Bone-marrow stem cells are used as part of comprehensive surgical treatment, for example during knee arthroscopy. During surgery, they are collected from the operated area and then used to support repair processes in the joint, for example after meniscal repair or cartilage-repair techniques.
Postoperative care
After adipose-tissue stem-cell therapy, the patient goes home after a few hours. Depending on the orthopaedic indication, care may differ slightly. Usually it involves walking with elbow crutches for several days and avoiding non-steroidal anti-inflammatory drugs for seven days. A plaster dressing remains over the abdominal harvest site for seven days to prevent haematomas.
When bone-marrow stem cells are used during arthroscopy, no special postoperative measures are required. Care depends on the procedure performed.
Who can undergo procedures using PRP platelet-rich plasma?
All patients with broadly understood healing problems, or patients wishing to accelerate healing.
Contraindications to stem-cell therapy.
- past or active cancer
- autoimmune disease

